, , , , ,

Edgewood ArsenalEdgewood Arsenal Chemical Agent Exposure Studies

From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at Edgewood Arsenal, Maryland. The purpose was to evaluate the impact of chemical warfare agents on military personnel and to test biological and chemical weapons, pharmaceuticals, and vaccines. Some of these studies were directed at psycho-chemical warfare and grouped under the prosaïc title of the “Medical Research Volunteer Program” (1956-1975). The MRVP was also driven by “intelligence requirements” and the need for new and more effective interrogation techniques.

Overall, about 7,000 soldiers took part in these experiments that involved exposures to more than 250 different chemicals, according to the Department of Defense (DoD). Some of the “volunteers” exhibited symptoms at the time of exposure to these agents but long-term follow-up was not planned as part of the DoD studies. The experiments were allegedly terminated by the Army in late 1975 in an atmosphere of scandal and recrimination as lawmakers accused researchers of “questionable ethics.” Many official government reports and civilian lawsuits followed in the wake of the controversy.

The chemical agents tested on volunteers included chemical warfare agents and other related agents:

Background and rationale

human experimentAfter World War II, U.S. military researchers obtained formulas for the three nerve gases developed by the Nazis — tabun, soman, and sarin — and conducted studies on them at the U.S. Army Chemical Center at Edgewood. These studies included a secret human subjects component at least as early as 1948, when “psychological reactions” were documented in Edgewood technicians. Initially, such studies focused solely on the lethality of the gases and its treatment and prevention. A classified report entitled “Psycho-chemical Warfare: A New Concept of War” was produced in 1949 by Luther Wilson Greene, Technical Director of the Chemical and Radiological Laboratories at Edgewood. Greene called for a search for novel psychoactive compounds that would create the same debilitating mental side effects as those produced by nerve gases, but without their lethal effect. In his words,

Throughout recorded history, wars have been characterized by death, human misery, and the destruction of property; each major conflict being more catastrophic than the one preceding it…I am convinced that the techniques of psycho-chemical warfare, is to conquer an enemy without the wholesale killing of his people or the mass destruction of his property.”

Greene also identified over 60 chemical agents that would disable humans mentally / psychology.

Hallucinogenic AgentsHallucinogenic agents (principally LSD) were tested on human subjects primarily at Edgewood Arsenal. The aim of this experimentation was to determine the effects of these chemicals on the nervous systems and mental functions of individuals and to evaluate preventive and therapeutic (treatment) agents to combat these effects.

In the late 1940s and early ’50s, the U.S. Army worked with Harvard anesthesiologist Henry K. Beecher at its interrogation center at Camp King in Germany on the use of psychoactive compounds (mescaline, LSD), including human subject experiments and the debriefing of former Nazi physicians and scientists who had worked along similar lines before the end of the war. In the 1950s, some officials in the U.S. Department of Defense publicly asserted that many “forms of chemical and allied warfare as more ‘humane’ than existing weapons. For example, certain types ofPsycho-chemical warfare‘ make it possible to paralyze temporarily entire population centers without damage to homes and other structures.” Soviet advances in the same field were cited as a special incentive giving impetus to research efforts in this area, according to testimony by Maj. Gen. Marshall Stubbs, the Army’s chief chemical officer.

General William M. Creasy, former chief chemical officer, U.S. Army, testified to the U.S. House of Representatives in 1959 that “provided sufficient emphasis is put behind it, I think the future lies in the psycho-chemicals.” This was alarming enough to a Harvard psychiatrist, E. James Lieberman, that he published an article entitled “Psycho-chemicals as Weapons” in The Bulletin of the Atomic Scientists in 1962. Lieberman, while acknowledging that “most of the military data” on the research ongoing at the Army Chemical Center was “secret and unpublished,” asserted that “There are moral imponderables, such as whether insanity, temporary or permanent, is a more ‘humane’ military threat than the usual afflictions of war.”

The experiments

Operation DeliriumThe Edgewood Arsenal human experiments took place from approximately 1948 to 1975 at the Medical Research Laboratories — which is now known as the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) — at the Edgewood Area, Aberdeen Proving Ground, Maryland. The experiments involved at least 254 chemical substances, but focused mainly on midspectrum incapacitants, such as LSD, THC derivatives, benzodiazepines, and BZ. In addition to the 7,000 US military personnel, there was at least 1,000 civilians were test subjects over almost three decades. A concrete result of these experiments was that BZ could be weaponized.

According a DOD FAQ, the Edgewood Arsenal experiments involved the following “rough breakout of volunteer hours against various experimental categories:”

Experimental category Percentage of volunteer hours
Incapacitating compounds 29.9%
Lethal compounds 14.5%
Riot control compounds 14.2%
Protective equipment and clothing 13.2%
Development evaluation and test procedures 12.5%
Effects of drugs and environmental stress on human physiological mechanisms 6.4%
Human factors tests (ability to follow instructions) 2.1%
Other (visual studies, sleep deprivation, etc.) 7.2%

An “Independent Study Course” for continuing medical education produced by the US Department of Veterans Affairs, Health Effects from Chemical, Biological, and Radiological Weapons (October 2003), presents the following summary of the Edgewood Arsenal experiments:

Renewed interest led to renewed human testing by the Department of Defense (DoD), although ultimately on a much smaller scale. Thus, between 1950 and 1975, about 6,720 soldiers took part in experiments involving exposures to 254 different chemicals, conducted at U.S. Army Laboratories at Edgewood Arsenal, MD (NRC 1982, NRC 1984, NAS 1993). Congressional hearings into these experiments in 1974 and 1975 resulted in disclosures, notification of subjects as to the nature of their chemical exposures, and ultimately to compensation for a few families of subjects who had died during the experiments (NAS 1993). These experiments were conducted primarily to learn how various agents would affect humans (NRC 1982). Other agencies including the CIA and the Special Operations Division of the Department of the Army were also reportedly involved in these studies (NAS 1993). Only a small number of all the experiments done during this period involved mustard agents or Lewisite. Records indicate that between 1955 and 1965, of the 6,720 soldiers tested, only 147 human subjects underwent exposure to mustard agent at Edgewood (NRC 1982).

According to the 1984 NRC review, human experiments at DoD’s Edgewood Arsenal involved about 1,500 subjects who were experimentally exposed to irritant and blister agents including:

For example, from 1958 to 1973 at least 1,366 human subjects underwent experimental exposure specifically with the riot-control agent CS at Edgewood Arsenal (NRC 1984). Of those involved in the experiments:

  • 1,073 subjects were exposed to aerosolized CS;
  • 180 subjects were exposed dermally;
  • 82 subjects had both skin applications and aerosol exposures; and finally
  • 31 subjects experienced ocular exposure via direct CS application to their eyes.Human ExperimentsMost of these experiments involved tests of protective equipment and of subjects’ ability to perform military tasks during exposure.

Similarly, cholinesterase reactivators antidotes such as 2-PAM were tested on about 750 subjects. These agents are still used today as antidotes to organophosphorus nerve agent poisoning, including accidental poisoning by organophosphorus pesticides. About 260 subjects were experimentally exposed to various psychochemicals including phencyclidine (PCP), and 10 related synthetic analogs of the active ingredient of cannabis (NRC 1984). The NRC report also mentions human experiments involving exposure of 741 soldiers to LSD (NRC 1984). Finally, from 1962 to 1972, a total of 123 irritant chemicals were tested on only two subjects each exposed using a wind tunnel (NRC 1984). These irritant chemicals were selected for human testing following preliminary animal studies.

The “Independent Study Course” cites mainly a three-volume study by the Institute of Medicine (1982–1985) for its data and conclusions, Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Some additional information in the section cited from the Course was based on a 1993 IOM study, Veterans at Risk: Health Effects of Mustard Gas and Lewisite.

A significant omission from the Course summary above is the number of subjects on which BZ and related compounds were tested. According to the memoirs of James Ketchum, who also cites the IOM study for the data, “24 belladonnoid glycolates and related compounds” were “given to 1,800 subjects”. The IOM study also concluded that “available data suggest that long-term toxic effects and/or delayed sequellae are unlikely” for this type of compound.[15]

In the mid-1970s, in the wake of many health claims made regarding exposure to the agents, the U.S. Congress began investigations of possible abuse in experiments and of inadequate informed consent given to the soldiers and civilians involved.

Scandal and termination

In September 1975, the Medical Research Volunteer Program was discontinued and all resident volunteers were removed from the Edgewood installation. The founder and director of the program, Dr Van Murray Sim, was called before Congress and chastized by outraged lawmakers, who questioned the absence of follow-up care for the human volunteers. An Army investigation subsequently found no evidence of serious injuries or deaths associated with the MRVP, but deplored both the recruiting process and the informed consent approach, which they characterized as “suggesting possible coersion.”


Government reports

1982-85 IOM report
The Institute of Medicine (IOM) published a three-volume report on the Edgewood research in 1982–1985, Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents.

The three volumes were:

  • Vol. 1, “Anticholinesterases and Anticholinergics” (1982).
  • Vol. 2, “Cholinesterase Reactivators, Psychochemicals and Irritants and Vesicants” (1984)
  • Vol. 3, “Final Report: Current Health Status of Test Subjects” (1985)

The National Academy of Sciences, which oversees the IOM, sent a questionnaire to all of the former volunteers that could be located, approximately 60% of the total. The lack of a detailed record hampered the investigation. The study could not rule out long-term health effects related to exposure to the nerve agents. It concluded that “Whether the subjects at Edgewood incurred these changes [depression, cognitive deficits, tendency to suicide] and to what extent they might now show these effects are not known”. With regard specifically to BZ and related compounds, the IOM study concluded that “available data suggest that long-term toxic effects and/or delayed sequellae are unlikely”.

2004 GAO report
A Government Accounting Office report of May 2004, Chemical and Biological Defense: DOD Needs to Continue to Collect and Provide Information on Tests and Potentially Exposed Personnel (pp. 1, 24), stated:

[In 1993 and 1994] we … reported that the Army Chemical Corps conducted a classified medical research program for developing incapacitating agents. This program involved testing nerve agents, nerve agent antidotes, psycho chemicals, and irritants. The chemicals were given to volunteer service members at Edgewood Arsenal, Maryland; Dugway Proving Ground, Utah; and Forts Benning, Bragg, and McClellan. In total, Army documents identified 7,120 Army and Air Force personnel who participated in these tests. Further, GAO concluded that precise information on the scope and the magnitude of tests involving human subjects was not available, and the exact number of human subjects might never be known.[17]

Safety debates

The “official position” of the Department of Defense, based on three-volume set of studies by the Institute of Medicine mentioned above, is that they “did not detect any “significant long-term health effects” on the Edgewood Arsenal “volunteers.” The safety record of the Edgewood Arsenal experiments was also defended in the memoirs of psychiatrist and colonel James Ketchum, a key scientist:

Over a period of 20 years, more than 7,000 volunteers spent an estimated total of 14,000 months at Edgewood Arsenal. To my knowledge, not one of them died or suffered a serious illness or permanent injury. That adds up to 1,167 man-years of survival. Statistically, at least one out of a thousand young soldiers chosen at random might be expected to expire during any one-year period. By this logic, Edgewood was possibly the “safest military place” in the world to spend two months.

Even a book critical of the program, written by Lynn C. Klotz and Edward J. Sylvester, acknowledges that:

Unlike the CIA program, research subjects [at Edgewood] all signed informed consent forms, both a general one and another related to any experiment they were to participate in. Experiments were carried out with “safety of subjects” a principal focus. […] At Edgewood, even at the highest doses it often took an hour or more for incapacitating effects to show, and the end-effects usually did not include full incapacitation, let alone unconsciousness. After all, the Edgewood experimenters were focused on disabling soldiers in combat, where there would be tactical value simply in disabling the enemy.[8

In the 1990s, the law firm Morrison & Foerster agreed to take on a class-action lawsuit against the government related to the Edgewood volunteers. The plaintiffs collectively referred to themselves as the “Test Vets”.

EdgewoodCase_Chemical-Testing-Chamber-300x204In 2009 a lawsuit was filed by veterans rights organizations Vietnam Veterans of America, and Swords to Plowshares, and eight Edgewood veterans or their families against CIA, the U.S. Army, and other agencies. The complaint asked the court to determine that defendants’ actions were illegal and that the defendants have a duty to notify all victims and to provide them with health care. In the suit, Vietnam Veterans of America, et al. v. Central Intelligence Agency, et al. Case No. CV-09-0037-CW, U.S.D.C. (N.D. Cal. 2009), the plaintiffs did not seek monetary damages. Instead, they sought only declaratory and injunctive relief and redress for what they claimed was several decades of neglect and the U.S. government’s use of them as human guinea pigs in chemical and biological agent testing experiments.

The plaintiffs cited:

  • The use of troops to test nerve gas, psychochemicals, and thousands of other toxic chemical or biological substances.
  • A failure to secure informed consent and other widespread failures to follow the precepts of U.S. and international law regarding the use of human subjects, including the 1953 Wilson Directive and the Nuremberg Code.
  • A refusal to satisfy their legal and moral obligations to locate the victims of experiments or to provide health care or compensation to them
  • A deliberate destruction of evidence and files documenting their illegal actions, actions which were punctuated by fraud, deception, and a callous disregard for the value of human life.

On July 24, 2013, United States District Court Judge Claudia Wilken issued an order granting in part and denying in part plaintiffs’ motion for summary judgment and granting in part and denying in part defendants’ motion for summary judgment. The court resolved all of the remaining claims in the case and vacated trial.

Psycho Chemicals as WeaponsThe court granted the plaintiffs partial summary judgment concerning the notice claim: summarily adjudicating in plaintiffs’ favor, finding that “the Army has an ongoing duty to warn” and ordering “the Army, through the DVA or otherwise, to provide test subjects with newly acquired information that may affect their well-being that it has learned since its original notification, now and in the future as it becomes available.” The court granted the defendants’ motion for summary judgment with respect to the other claims.

Material Testing Program EA (Edgewood Arsenal) numbers

  • EA 1298 – A mescaline variant
  • EA 1476 – A dimethylheptylpyran variant (“red oil”)
  • EA 1729LSD
  • EA 2233-Adimethylheptylpyran variant
    • Eight individual isomers numbered EA-2233-1 through EA-2233-8
  • EA 2277BZ (“Substance 78” to Soviets)
  • EA 3148 – A “V-series” nerve agent (“Substance 100A” to Soviets)
  • EA 3167 – A BZ variant
  • EA 3443 – A BZ variant
  • EA 3580 – A BZ variant
  • EA 3834 – A BZ variant

See also


  • Two autobiographical books from psychiatrists conducting human experiments at Edgewood have been self-published:
    • Men and Poisons: The Edgewood Volunteers and the Army Chemical Warfare Research Program (2005), Xlibris Corporation, 140pp, was written by Malcolm Baker Bowers Jr, who went on to become a prof of psychiatry at Yale. Bowers’ book is a “fictionalized” account with names changed.
    • Chemical Warfare Secrets Almost Forgotten, A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War (1955-1975) (2006, 2nd edition 2007), foreword by Alexander Shulgin, ChemBook,Inc., 360 pp, was written by Ketchum who was a key player after 1960 and went on to become a professor at the University of California-Los Angeles.
  • The Vanderbilt University Television News Archive has two videos about the experiments, both from a July 1975 NBC Evening News segment.
    • NBC newsman John Chancellor reported on how Norman Augustine, then-acting Secretary of Army, ordered a probe of Army use of LSD in soldier and civilian experiments.
    • Correspondent Tom Pettit reported on Major General Lloyd Fellenz, from Edgewood Arsenal, who explained how the experiments there were about searching for humane weapons, adding that the use of LSD was unacceptable.
  • Journalist Linda Hunt, citing records from the U.S. National Archives, revealed that eight German scientists worked at Edgewood, under Project Paperclip. Hunt used this finding to assert that in this collaboration, US and former Nazi scientists “used Nazi science as a basis for Dachau-like experiments on over 7,000 U.S. soldiers.”
  • A Washington Post article, dated July 23, 1975, by Bill Richards (“6,940 Took Drugs”) reported that a top civilian drug researcher for the Army said a total of 6,940 servicemen had been involved in Army chemical and drug experiments, and that, furthermore, the tests were proceeding at Edgewood Arsenal as of the date of the article.
  • Two TV documentaries, with different content but confusingly similar titles were broadcast:
    • Bad Trip to Edgewood (1993) on ITV Yorkshire
    • Bad Trip to Edgewood (1994) on A&E Investigative Reports.
  • In 2012, the Edgewood/Aberdeen experiments were featured on CNN and in The New Yorker magazine.


External links