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DepressionInflammation-657x360Barely a week goes by without a celebrity “opening up” about their “battle with depression”. This, apparently, is a brave thing to do because, despite all efforts to get rid of the stigma around depression, it is still seen as some kind of mental and emotional weakness.

But what if was nothing of the sort? What if it was a physical illness that just happens to make people feel pretty lousy? Would that make it less of a big deal to admit to? Could it even put a final nail in the coffin of the idea that depression is all in the mind?

According to a growing number of scientists, this is exactly how we should be thinking about the condition. George M. Slavich, a clinical psychologist at the UCLA Laboratory for Stress Assessment and Research in Los Angeles, has spent years studying depression, and has come to the conclusion that it has as much to do with the body as the mind. “I don’t even talk about it as a psychiatric condition any more,” he says. “It does involve psychology, but it also involves equal parts of biology and physical health.”

The basis of this new view is blindingly obvious once it is pointed out: everyone feels miserable when they are ill. That feeling of being too tired, bored and fed up to move off the sofa and get on with life is known among psychologists as sickness behavior. It happens for a good reason, helping us avoid doing more damage or spreading an infection any further.

It also looks a lot like depression. So if people with depression show classic sickness behavior and sick people feel a lot like people with depression – might there be a common cause that accounts for both?

The answer to that seems to be yes, and the best candidate so far is inflammation – a part of the immune system that acts as a burglar alarm to close wounds and call other parts of the immune system into action. A family of proteins called cytokines sets off inflammation in the body, and switches the brain into sickness mode.

This new research is revealing that many cases of depression are caused by an allergic reaction to inflammation.  Tim de Chant of NOVA writes: “Inflammation is our immune system’s natural response to injuries, infections, or foreign compounds. When triggered, the body pumps various cells and proteins to the site through the blood stream, including cytokines, a class of proteins that facilitate intercellular communication.  It also happens that people suffering from depression are loaded with cytokine .”

Some think the inflammatory response may be spurred by an infection of some kind.  Others think obesity or modern high-trans-fat, high-sugar diets could be the cause. Still others say that stress from bullying, rejection, or loneliness may be to blame.

depression-and-inflammationCytokines, known to promote inflammation, are increased in the bodies and brains of people who are contemplating or have attempted suicide.

Eleanor Morgan of VICE adds: “Both cytokines and inflammation have been shown to rocket during depressive episodes, and – in people with bipolar – to drop off in periods of remission.. Healthy people can also be temporarily put into a depressed, anxious state when given a vaccine that causes a spike in inflammation. Brain imaging studies of people injected with a typhoid vaccine found that this might be down to changes in the parts of the brain that process reward and punishment.”

As evidence like this continues to stack up, it’s not surprising that some people have shifted their attention to what might be causing the inflammation in the first place. Turhan Canli of Stony Brook University in New York thinks infections are the most likely culprit, and even goes as far as to say that we should rebrand depression as an infectious – but not contagious – disease.

InflammationOthers aren’t willing to go that far, not least because infection is not the only way to set off inflammation. A diet rich in trans fats and sugar has been shown to promote inflammation, while a healthy one full of fruit, veg and oily fish helps keep it at bay. Obesity is another risk factor, probably because body fat, particularly around the belly, stores large quantities of cytokines.

Add this to the fact that stress, particularly the kind that follows social rejection or loneliness, also causes inflammation, and it starts to look as if depression is a kind of allergy to modern life – which might explain its spiraling prevalence all over the world as we increasingly eat, sloth and isolate ourselves into a state of chronic inflammation.

If that’s the case, prevention is probably the place to start. It’s not a great idea to turn off inflammation entirely, because we need it to fend off infections, says Slavich, but “lowering levels of systemic inflammation to manageable levels is a good goal to have”.

There are also others who think we should re-brand depression altogether as an infectious disease … Carmine Pariante, a King’s College psychiatrist who said:

“People with inflammatory diseases such as rheumatoid arthritis tend to suffer more than average with depression; cancer patients given a drug called Interferon alfa , which boosts their inflammatory response to help fight the cancer, often become depressed as a side-effect.. We’re between five and ten years away from a blood test that can measure levels of inflammation in depressed people.” 

And as for the stigma – could it really be killed off by shifting the blame from the mind to the body? Time will tell. This is not the first time that depression has been linked to a physical phenomenon, after all. A recent survey found that despite wider awareness of the theory that “chemical imbalances” in the brain cause depression, this has done nothing to reduce stigma; in fact, it seemed to make matters worse.

This time, though, the target is not any kind of brain or mind-based weakness but a basic feature of everyone’s body that could strike anyone down given the right – or wrong – turn of events. And if that doesn’t inspire a greater sympathy and understanding, then nothing will.

InflammationTIMEIt may be some years before scientists are finally able to sort out what the exact source of the inflammation, and it’s possible that different people will be susceptible to different causes. When they do, we’ll might add depression to the growing list of ailments—from allergies to heart disease and Alzheimer’s—that are caused or affected by an immune response gone wrong.

By treating the inflammatory symptoms of depression — rather than the neurological ones — researchers and doctors are opening up an exciting new dimension in the fight against what has become a global epidemic.

The good news is that the few clinical trials done so far have found that adding anti-inflammatory medicines to antidepressants not only improves symptoms, it also increases the proportion of people who respond to treatment, although more trials will be needed to confirm this. There is also some evidence that omega 3 and curcumin, an extract of the spice turmeric, might have similar effects. Both are available over the counter and might be worth a try, although as an add-on to any prescribed treatment – there’s definitely not enough evidence to use them as a replacement.

If Pariante’s estimate and the inflammation-depression theory are correct, we could potentially be just five years from an adequate ‘cure’ for depression.

Charlie Rose Brain Series 2: Depression

Charlie Rose Depression– Click image above to watch video.


Note: For more in depth information on the role of inflammation in mental health, please see Professor Pariante’s lecture “The Ghost of Inflammation” on the King’s Medicine YouTube channel.

You can read much more by visiting The GuardianVICE, and NOVA.  And to learn much more about how food and mood are powerfully connected, be sure to read this fascinating article on Kripalu.org. (Image courtesy of the American Heart Association).



Scholarly articles for Depression and Inflammation

Is Your Diet Making You Anxious or Depressed?

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Could Depression Actually Be Nothing More Than an …

Depression May Be Caused by Inflammation — NOVA

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